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Home >> Antibodies >> Mammaglobin (SCGB2A2) (Breast Cancer Marker)

Mammaglobin (SCGB2A2) (Breast Cancer Marker)

Recombinant Rabbit Monoclonal Antibody [Clone MGB/4057R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Mammaglobin Recombinant Rabbit Monoclonal Antibody (MGB/4057R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Mammaglobin Recombinant Rabbit Monoclonal Antibody (MGB/4057R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

Analysis of Protein Array containing >19,000 full-length human proteins using Mammaglobin Monospecific Recombinant Rabbit Monoclonal Antibody (MGB/4057R).

Product Details

Synonyms

Mammaglobin-1 (MGB1); Mammaglobin-A; Secretoglobin family 2A member 2 (SCGB2A2); SG2A2; UGB2

Positive Control

HeLa or MCF-7 cells. Mammary gland specific. Overexpressed in breast cancer.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human SCGB2A2 (Mammaglobin-1) protein

Cellular Localization

Cytoplasmic expression in ductal cells. Additional plasma positivity in lactating breast.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

18kDa

Specificity & Comments

Mammaglobin is a 93 amino acid glycoprotein with homology to other secretoglobin-uteroglobin family members. It was originally identified as a breast cancer restricted biomarker by differential screening. Mammaglobin related to secretoglobin family that includes human uteroglobin and lipophilin. Mammaglobin antibody stains cytoplasm of normal breast epithelial cells as well as primary and metastatic breast carcinomas. Mammaglobin expression is absent in prostate, kidney, colon, rectum, small intestine, stomach, pancreas, lung, and thyroid tissues.Mammaglobin may be used as part of an immunohistochemical panel for determination of metastatic breast carcinoma and tumor of unknown primary origin.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bioinformatics

  •  Entrez Gene ID: 4250
  •  Gene Symbol: SCGB2A2
  •  SwissProt: Q13296
  •  Chromosome Location: 11q12.3
  •  Unigene: 46452