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Home >> Antibodies >> Inhibin, alpha (INHA) (Gonadal Cell Marker)

Inhibin, alpha (INHA) (Gonadal Cell Marker)

Recombinant Rabbit Monoclonal Antibody [Clone INHA/6598R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

IHC analysis of formalin-fixed, paraffin-embedded human testicular carcinoma. Staining with INHA/6598R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using INHA/6598R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

img

SDS-PAGE Analysis Purified Inhibin ’ Recombinant Rabbit Monoclonal Antibody (INHA/6598R). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human testis stained with Inhibin ’ Recombinant Rabbit Monoclonal Antibody (INHA/6598R).

Product Details

Synonyms

A inhibin subunit; IHA; inhA; Inhibin alpha chain; Inhibin alpha subunit

Positive Control

Human prostate or testis.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human Inhibin alpha protein (around aa 233-362) (exact sequence is proprietary)

Cellular Localization

Nucleus. Cytoplasm (secreted).

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

47kDa

Specificity & Comments

It recognizes a 47kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same subunit, covalently linked to 1 of 2 distinct subunits, - or -. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor (TFG) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. Inhibin antibody is also used to make the differential diagnosis of intra-uterine vs. ectopic pregnancy in endometrial curetting.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Balanathan, P., et al. (2009) Elevated level of inhibin-αsubunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer. British Journal of Cancer, 100(11), 1784 1793.

Bioinformatics

  •  Entrez Gene ID: 3623
  •  Gene Symbol: INHA
  •  SwissProt: P05111
  •  Chromosome Location: 2q35
  •  Unigene: 407506