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Inhibin, alpha (INHA) (Gonadal Cell Marker) Antibody [R1]

Additional information

Catalog Number: 3623-MSM7
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

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In Stock
Catalog Number Formulation Size Price
3623-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3623-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3623-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Inhibin, alpha (INHA) (Gonadal Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Inhibin, alpha Mouse Monoclonal Antibody (R1).

Inhibin, alpha (INHA) (Gonadal Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Inhibin, alpha Mouse Monoclonal Antibody (R1).

Inhibin, alpha Antibody in SDS-PAGE

Inhibin, alpha Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Inhibin, alpha Mouse Monoclonal Antibody (R1). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
R1
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Secreted
Gene Name
INHA
Positive Control
Human prostate or testis.
Immunogen
A synthetic peptide corresponding to Human Inhibin alpha aa 233-264. Note that this peptide corresponds to the N-terminus of the mature region of the human inhibin alpha subunit.
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Key References
  • Balanathan, P., et al. (2009) Elevated level of inhibin-αsubunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer. British Journal of Cancer, 100(11), 1784 1793.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3623
SwissProt
P05111
Chromosome Location
2q35
Mol. Weight of Antigen
47kDa
Alternate Names
Inhibin alpha chain, A inhibin subunit; IHA; inhA; Inhibin alpha chain; Inhibin alpha subunit

Summary

It recognizes a 47kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same 伪 subunit, covalently linked to 1 of 2 distinct subunits, 尾-伪 or 尾-尾. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor 尾 (TFG尾) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. Inhibin antibody is also used to make the differential diagnosis of intra-uterine vs. ectopic pregnancy in endometrial curetting.

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