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Home >> Antibodies >> Homeobox and Leucine Zipper Encoding / HOMEZ

Homeobox and Leucine Zipper Encoding / HOMEZ

Mouse Monoclonal Antibody [Clone PCRP-HOMEZ-1A5]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human lymph node stained with HOMEZ Mouse Monoclonal Antibody (PCRP-HOMEZ-1A5).

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Flow cytometric analysis of PFA-fixed HeLa cells. HOMEZ Mouse Monoclonal Antibody (PCRP-HOMEZ-1A5) followed by goat anti-mouse IgG-CF488 (blue), isotype control (red).

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SDS-PAGE Analysis Purified HOMEZ Mouse Monoclonal Antibody (PCRP-HOMEZ-1A5). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using EIF2S1 Mouse Monoclonal Antibody (PCRP-HOMEZ-1A5).

Product Details

Synonyms

KIAA1443, Homeodomain leucine zipper-containing factor

Positive Control

Human testis, kidney or fetal lung.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human HOMEZ protein

Cellular Localization

Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b

Mol. Weight of Antigen

61.24kDa

Specificity & Comments

Homeodomain-containing proteins function as transcription factors that typically switch on cascades of other genes. Usually homeodomain proteins act in the promoter region of their target genes as complexes with other transcription factors, leading to much higher target specificity than a single homeodomain protein. HOMEZ (Homeobox and leucine zipper protein) is a 525 amino acid nuclear protein that contains 3 atypical homeodomains, 2 leucine zipper-like motifs, proline and serine-rich motifs and an acidic domain. Within homeodomain 2, it contains a putative nuclear localization signal. HOMEZ shares significant sequence similarity with mouse ZHX1 and sequences that are homologous to HOMEZ are restricted to vertebrates. Likely functioning as a transcription regulator, HOMEZ is ubiquitously expressed with highest levels found in in ovary, testis, kidney, fetal lung and kidney.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Blackshaw S., et al. Nature methods 15.5 (2018 May): 330-338.
  2. Nagase, T, et al. DNA Res. 2000 Feb 28;7(1):65-73.

Bioinformatics

  •  Entrez Gene ID: 57594
  •  Gene Symbol: HOMEZ
  •  SwissProt: Q8IX15
  •  Chromosome Location: 14q11.2
  •  Unigene: 632332