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Homeobox and Leucine Zipper Encoding / HOMEZ Antibody [PCRP-HOMEZ-1A5]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
57594-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
57594-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
57594-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Homeodomain-containing proteins function as transcription factors that typically switch on cascades of other genes. Usually homeodomain proteins act in the promoter region of their target genes as complexes with other transcription factors, leading to much higher target specificity than a single homeodomain protein. HOMEZ (Homeobox and leucine zipper protein) is a 525 amino acid nuclear protein that contains 3 atypical homeodomains, 2 leucine zipper-like motifs, proline and serine-rich motifs and an acidic domain. Within homeodomain 2, it contains a putative nuclear localization signal. HOMEZ shares significant sequence similarity with mouse ZHX1 and sequences that are homologous to HOMEZ are restricted to vertebrates. Likely functioning as a transcription regulator, HOMEZ is ubiquitously expressed with highest levels found in in ovary, testis, kidney, fetal lung and kidney.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Nucleus
Gene Name
Positive Control
Human testis, kidney or fetal lung.
Immunogen
Recombinant full-length human HOMEZ protein
Alternate Names
Homeobox and leucine zipper protein Homez, Homeodomain leucine zipper-containing factor, KIAA1443, Homeodomain leucine zipper-containing factor

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-HOMEZ-1A5
Chromosome Location
14q11.2
Mol. Weight of Antigen
61.24kDa

Functions

  • May function as a transcriptional regulator.

Key References

  • Blackshaw S., et al. Nature methods 15.5 (2018 May): 330-338.
  • Nagase, T, et al. DNA Res. 2000 Feb 28;7(1):65-73.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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