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Home >> Antibodies >> Fetuin / AHSG (alpha 2-HS glycoprotein)

Fetuin / AHSG (alpha 2-HS glycoprotein)

Mouse Monoclonal Antibody [Clone AHSG/3748]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human placenta stained with Fetuin / AHSG Mouse Monoclonal Antibody (AHSG/3748) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control.

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SDS-PAGE Analysis Purified Fetuin / AHSG Mouse Monoclonal Antibody (AHSG/3748). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Fetuin / AHSG Monospecific Mouse Monoclonal Antibody (AHSG/3748).

Product Details

Synonyms

59 kDa bone sialic acid-containing protein; Aa2-066; AHS; A-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; HSGA Asialofetuin; Ba-alpha-2-glycoprotein; BSP; Countertrypin; Fetua; Fetuin A; Glycoprotein PP63

Positive Control

Human liver, testis or placenta.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human AHSG protein (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

59kDa

Specificity & Comments

Fetuin (also designated 2-z-globulin or 2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lebreton, J.P., et al. 1979. Serum concentration of human α2-HS glycoprotein during the inflammatory process: evidence that α2-HS glycoprotein is a negative acute-phase reactant. J. Clin. Invest. 64: 1118-1129.

Bioinformatics

  •  Entrez Gene ID: 197
  •  Gene Symbol: AHSG
  •  SwissProt: P02765Human
  •  Chromosome Location: 3q27.3
  •  Unigene: 324746