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Fetuin / AHSG (alpha 2-HS glycoprotein) Antibody [AHSG/3748]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
197-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
197-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
197-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

Fetuin (also designated 伪2-z-globulin or 伪2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human liver, kidney, testisor placenta
Immunogen
Recombinant fragment of human AHSG protein (exact sequence is proprietary)
Alternate Names
Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, 59 kDa bone sialic acid-containing protein; Aa2-066; AHS; A-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; HSGA Asialofetuin; Ba-alpha-2-glycoprotein; BSP; Countertrypin; Fetua; Fetuin A; Glycoprotein PP63

Database Links

Entrez Gene ID
197
SwissProt

Additional Information

Clone
AHSG/3748
Chromosome Location
3q27.3
Mol. Weight of Antigen
59kDa

Functions

  • Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.

Key References

  • Lebreton, J.P., et al. 1979. Serum concentration of human α2-HS glycoprotein during the inflammatory process: evidence that α2-HS glycoprotein is a negative acute-phase reactant. J. Clin. Invest. 64: 1118-1129.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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