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Home >> Antibodies >> Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker)

Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker)

Biotinylated Mouse Monoclonal Antibody [Clone FTL/1386]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

499.00

Formulation

Purified Ab conjugated to Biotin

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to Biotin

Price (USD)

499.00
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Formalin-fixed, paraffin-embedded human kidney stained with Biotinylated Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1386).

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Formalin-fixed, paraffin-embedded human kidney stained with Biotinylated Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1386).

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SDS-PAGE Analysis Purified Ferritin LC Mouse Monoclonal Antibody (FTL/1386) (unconjugated). Confirmation of Integrity and Purity of Antibody

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1386)

Product Details

Synonyms

Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; FTL; LFTD; NBIA3

Positive Control

HepG2, HeLa or 293T cells. Human pancreas, liver, cerebellum or testis.

Known Applications & Suggested Dilutions

ELISA, Western Blot, IHC-P         More Details

ELISA (For coating, order Ab without BSA)
Western Blot (2-4ug/ml)
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °
C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 38-165) of human FTL protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

19-25kDa

Specificity & Comments

Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

Related Products



Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Key References

  1. J z quel P, et. al. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study Int. J Cancer. 2012;131(2):426-37.
  2. Y.Kaneko,et al. Ferritin immunohistochemistry as a marker for microglia. Acta Neuropathologica. 1989,Volume 79; 129-136.

Bioinformatics

  •  Entrez Gene ID: 2512
  •  Gene Symbol: FTL
  •  SwissProt: P02792
  •  Chromosome Location: 19q13.33
  •  Unigene: 433670