Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker) [FTL/1389]

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Summary

Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

Product Properties & Targets

Host
Species Reactivity
Isotype
Gene Name
FTL
Mol. Weight of Antigen
19-25kDa
Immunogen
Recombinant fragment (around aa 38-165) of human FTL protein (exact sequence is proprietary)

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
FTL/1389
Human Gene Symbol
FTL
Chromosome Location
19q13.33

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA)
  • Western Blot (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Y.Kaneko,T.Kitamoto,J.Tateishi,K.Yamaguchi. Ferritin immunohistochemistry as a marker for microglia. Acta Neuropathologica. 1989,Volume 79; 129-136
  • Jezequel P, et. al. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study Int. J Cancer. 2012;131(2):426-37

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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