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Recombinant Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker) Antibody [rFTL/1388]

In Stock
Catalog Number Formulation Size Price
2512-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
2512-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
2512-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker) Antibody

Formalin-fixed, paraffin-embedded human Pancreas stained with Ferritin, Light Chain Recombinant Mouse Monoclonal Antibody (rFTL/1388).

Recombinant Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Pancreas stained with Ferritin, Light Chain Recombinant Mouse Monoclonal Antibody (rFTL/1388).

Recombinant Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker) Antibody - Image 3

SDS-PAGE Analysis of Purified Ferritin LC Recombinant Mouse Monoclonal Antibody (rFTL/1388). Confirmation of Integrity and Purity of Antibody

Recombinant Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker) Antibody - Image 4

Western Blot Analysis of human Kidney tissue lysate using Ferritin LC Recombinant Mouse Monoclonal Antibody (rFTL/1388).

Ferritin Light Chain in Western Blot (WB)

Ferritin Light Chain in Western Blot (WB)

Western blot analysis of A-431 cell lysate using FTL Recombinant Mouse Monoclonal Antibody (rFTL/1388).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Dendritic Cell Marker
Isotype / Light Chain
IgG1 / Kappa
Gene Name
FTL
Positive Control
Cerebellum or Testis., HeLa, HePG2, HL-60 or 293T cells. Pancreas, Kidney, Liver
Immunogen
Recombinant fragment (around aa 38-165) of human FTL protein (exact sequence is proprietary)
Alternate Names
Ferritin light chain, Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; FTL; LFTD; NBIA3

Database Links

Entrez Gene ID
2512
SwissProt
P02792

Additional Information

Clone
rFTL/1388
Chromosome Location
19q13.33
Mol. Weight of Antigen
19-25kDa

Related Antibodies

View All FTL Antibodies

Functions

  • Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

Key References

  • Jezequel P, et. al. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study Int. J Cancer. 2012;131(2):426-37

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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