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Home >> Antibodies >> Complement 3d (C3d) (Acute Humoral Rejection Marker)

Complement 3d (C3d) (Acute Humoral Rejection Marker)

Mouse Monoclonal Antibody [Clone C3D/2891]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified Complement 3d Mouse Monoclonal Antibody (C3D/2891). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Complement C3d Mouse Monoclonal Antibody (C3D/2891)

Product Details

Synonyms

Acylation stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement component C3; CPAMD1

Positive Control

Human kidney or rejected renal transplant tissue.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Complement C3 protein

Cellular Localization

Plasma.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

35kDa (predicted)

Specificity & Comments

The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nagar, B., et al. 1998. X-ray crystal structure of C3d: a C3 fragment and ligand for CR2. Science 280: 1277-1281.
  2. Clemenza, L., et al. 2000. Structure-guided identification of C3d residues essential for its binding to CR2 (CD21). J. Immunol. 165: 3839-3848.

Bioinformatics

  •  Entrez Gene ID: 718
  •  Gene Symbol: C3
  •  SwissProt: P01024
  •  Chromosome Location: 19p13.3
  •  Unigene: 529053
NBT02891