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Home >> Antibodies >> c-Myc Oncoprotein

c-Myc Oncoprotein

Recombinant Rabbit Monoclonal Antibody [Clone MYC2895R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified c-Myc Rabbit Recombinant Monoclonal Antibody (MYC2895R). Confirmation of Purity and Integrity of Antibody.

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Flow Cytometric Analysis of K562 cells using c-Myc Rabbit Recombinant Monoclonal Antibody (MYC2895R) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).

Product Details

Synonyms

Class E basic helix-loop-helix protein 39 (bHLHe39), MRTL, Myc2, Niard, Nird, Proto-oncogene c-Myc, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, V-Myc avian myelocytomatosis viral oncogene homolog

Positive Control

K562, HL-60 cells. Cervical Carcinoma.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF         More Details

ELISA (For coating, order antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from C-terminus of human c-myc, coupled to KLH.

Cellular Localization

Nuclear

Species Reactivity

Human. Does not react with Mouse, Rat or Chicken.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

62-64kDa

Specificity & Comments

It recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Evan GI, et. al. Molecular and Cellular Biology, 1985, 5(12):3610-6.

Bioinformatics

  •  Entrez Gene ID: 4609
  •  Gene Symbol: MYC
  •  SwissProt: P01106
  •  Chromosome Location: 8q24.21
  •  Unigene: 202453
NBT02895