The molecular weight of the MYC (c-Myc) protein can vary based on post-translational modifications, but it is approximately 57-70 kDa. This transcription factor regulates the expression of a wide range of target genes and is expressed in various tissues and cell types during normal development and cellular processes. While MYC is vital for normal cell growth and development, its dysregulation can contribute to the development of various cancers, including Burkitt’s lymphoma, breast cancer, and colorectal cancer. Additionally, amplification or overexpression of MYC is a common genetic alteration in many human cancers.
Antibodies against MYC are used in research to study its expression levels in cells and tissues. Immunohistochemistry, Western blotting, and chromatin immunoprecipitation (ChIP) techniques employing anti-MYC antibodies help researchers investigate the role of MYC in cancer and other diseases. MYC expression is being explored as a potential prognostic marker in cancer.
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