The molecular weight of the MYC (c-Myc) protein can vary based on post-translational modifications, but it is approximately 57-70 kDa. This transcription factor regulates the expression of a wide range of target genes and is expressed in various tissues and cell types during normal development and cellular processes. While it is vital for normal cell growth and development, its dysregulation can contribute to the development of various cancers, including Burkitt’s lymphoma, breast cancer, and colorectal cancer. Additionally, its amplification or overexpression is a common genetic alteration in many human cancers.
Antibodies against MYC are used in research to study its expression levels in cells and tissues. Immunohistochemistry, Western blotting, and chromatin immunoprecipitation (ChIP) techniques employing anti-MYC antibodies help researchers investigate its role in cancer and other diseases. Its expression is being explored as a potential prognostic marker in cancer.
Synonyms
Myc proto-oncogene protein, MRTL|MYCC|bHLHe39|c-Myc
Research Areas
Apoptosis, Autophagy, Breast Cancer, Cancer, Cardiovascular, Cell Biology, Cellular Markers and Tags, Developmental Biology, Endocrine, Epigenetics, Gastrointestinal Tract, Hypoxia, Immuno Oncology, Immunology, Kidney, Lymphatic, Metabolism, Microbiology, Muscle, Neuroscience, Pancreatic Cancer, Prostate Cancer, Skin, Stem Cell, AKT Signaling, Angiogenesis, Articular Cartilage Extracellular Matrix, B Cell Markers, Basal Cell Marker, BBB VCAM-1 Signaling, Bladder Cancer, Cardiac Stem Cells, Colon Cancer, Colorectal Cancer, Complement System, CTLA-4 blockade immunotherapy, Cytokine Signaling, Defective Intrinsic Apoptosis, Dendritic Cell Marker, Digestion, Endothelial Cell Marker, Hematopoietic Stem Cells, Immune checkpoint, Infectious Disease, Lipid Metabolism, Lung Cancer, MAPK Signaling, Mast Cell Marker, Melanoma, Mesenchymal Stem Cell Differentiation, Mitochondria Marker, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Oncology, Ovarian Cancer, PD-1 blockade immunotherapy, Signal Transduction, Stem Cell Differentiation, Transcription Factors