The molecular weight of the MYC (c-Myc) protein can vary based on post-translational modifications, but it is approximately 57-70 kDa. This transcription factor regulates the expression of a wide range of target genes and is expressed in various tissues and cell types during normal development and cellular processes. While it is vital for normal cell growth and development, its dysregulation can contribute to the development of various cancers, including Burkitt’s lymphoma, breast cancer, and colorectal cancer. Additionally, its amplification or overexpression is a common genetic alteration in many human cancers.
Antibodies against MYC are used in research to study its expression levels in cells and tissues. Immunohistochemistry, Western blotting, and chromatin immunoprecipitation (ChIP) techniques employing anti-MYC antibodies help researchers investigate its role in cancer and other diseases. Its expression is being explored as a potential prognostic marker in cancer.
Synonyms
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, Proto-oncogene c-Myc, Transcription factor p64, Class E basic helix-loop-helix protein 39 (bHLHe39), MRTL, Myc2, Niard, Nird, Proto-oncogene c-Myc, RNCMYC, Transcription factor p64, Transcriptional regulator Myc-A, V-Myc avian myelocytomatosis viral oncogene homolog
Research Areas
Apoptosis, Autophagy, Breast Cancer, Cardiovascular, Developmental Biology, Immunology, Bladder Cancer, Colon Cancer, Cytokine Signaling, Infectious Disease, Lung Cancer, MAPK Signaling, Nuclear Marker, Signal Transduction, Stem Cell Differentiation, Transcription Factors
