SDS-PAGE Analysis Purified c-Myc Rabbit Recombinant Monoclonal Antibody (MYC2895R). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of K562 cells using c-Myc Rabbit Recombinant Monoclonal Antibody (MYC2895R) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).
It recognizes a transcription factor of 64-67kDa, identified as c-myc. Its epitope spans between aa 410-419 (EQKLISEEDL) which is a specific portion of an alpha helical region of human c-myc protein. This MAb shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease.
