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Home >> Antibodies >> CD46 (Membrane Cofactor Protein)

CD46 (Membrane Cofactor Protein)

Mouse Monoclonal Antibody [Clone 122.2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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FCM staining of human PBMCs using CD46 Mouse Monoclonal Antibody (122.2).

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SDS-PAGE Analysis Purified CD46 Mouse Monoclonal Antibody (122.2). Confirmation of Integrity and Purity of Antibody

Product Details

Synonyms

AHUS2; CD46 antigen complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen

Positive Control

HeLa, K-562 or MOLT-4 cells. Kidney.

Known Applications & Suggested Dilutions

Func., Flow Cyt, IF         More Details

Functional Studies (Order Ab without Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human CD46 protein

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

56-66kDa

Specificity & Comments

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Iwata, K., et al. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270: 15148-15152.
  2. Liszewski, M.K., et al. 1996. Control of the complement system. Adv. Immunol. 61: 201-283.
  3. Liszewski, M.K., et al. 1996. Membrane cofactor protein (MCP, CD46). Isoforms differ in protection against the classical pathway of complement. J. Immunol. 156: 4415-4421

Bioinformatics

  •  Entrez Gene ID: 4179
  •  Gene Symbol: CD46
  •  SwissProt: P15529
  •  Chromosome Location: 1q32.2
  •  Unigene: 510402
NBT00175