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CD46 (Membrane Cofactor Protein) Antibody [122.2]

Additional information

Catalog Number: 4179-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4179-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4179-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4179-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD46 (Membrane Cofactor Protein) Antibody

FCM staining of human PBMCs using CD46 Mouse Monoclonal Antibody (122.2).

CD46 (Membrane Cofactor Protein) Antibody - Image 2

SDS-PAGE Analysis of Purified CD46 Mouse Monoclonal Antibody (122.2). Confirmation of Integrity and Purity of Antibody

  • Flow
  • Functional Studies
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Human
Clone
122.2
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Acrosome inner membrane, Cytoplasmic vesicle, Secretory vesicle
Gene Name
CD46
Positive Control
HeLa, K-562 or MOLT-4 cells. Kidney.
Immunogen
Recombinant human CD46 protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
  • (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
  • (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.
  • (Microbial infection) Acts as a receptor for cultured Measles virus.
  • (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.
  • (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).
Key References
  • Iwata, K., et al. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270: 15148-15152.
  • Liszewski, M.K., et al. 1996. Control of the complement system. Adv. Immunol. 61: 201-283.
  • Liszewski, M.K., et al. 1996. Membrane cofactor protein (MCP, CD46). Isoforms differ in protection against the classical pathway of complement. J. Immunol. 156: 4415-4421
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4179
SwissProt
P15529
Chromosome Location
1q32.2
Mol. Weight of Antigen
56-66kDa
Alternate Names
Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, AHUS2; CD46 antigen complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen

Summary

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

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