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CD46 (Membrane Cofactor Protein) Antibody [MCP/931]

In Stock
Catalog Number Formulation Size Price
4179-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4179-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4179-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

Recognizes a protein of 52kDa-58kDa, identified as CD46. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Acrosome inner membrane, Cytoplasmic vesicle, Secretory vesicle
Gene Name
Positive Control
HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil., HL60, K562, U937
Immunogen
Recombinant human MCP protein
Alternate Names
Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
MCP/931
Chromosome Location
1q32
Mol. Weight of Antigen
52-58kDa

Functions

  • Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
  • (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
  • (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.
  • (Microbial infection) Acts as a receptor for cultured Measles virus.
  • (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.
  • (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

Key References

  • Kishimoto T. et al., eds. Leukocyte Typing VI, p506-509 and p1145-1146, Garland Publishing, Inc., New York and London, 1997.
  • Liszewski MK and Atkinson JP. Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complement. J Immunol 1996, 156:4415-4421.
  • Okada N et al. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A 1995, 92(7):2489-2493.
  • Blixenkrone-Moller M, et al. Role of CD46 in measles virus infection in CD46 transgenic mice. Virology 1998, 249(2):238-248
  • Kallstrom H et al. Cell signaling by the type IV pili of pathogenic Neisseria. J Biol Chem 1998, 273(34):21777-82

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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