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Home >> Antibodies >> CD205 / LY75 / DEC-205

CD205 / LY75 / DEC-205

Mouse Monoclonal Antibody [Clone CD205/3720]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human kidneystained with LY75 / DEC205Mouse Monoclonal Antibody (CD205/3720). Inset: PBS instead of primary antibody, secondary negative control.

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SDS-PAGE Analysis Purified LY75 / DEC205 Mouse Monoclonal Antibody (CD205/3720). Confirmation of Integrity and Purity of Antibody.

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Formalin-fixed, paraffin-embedded human colonstained with LY75 / DEC205 Mouse Monoclonal Antibody (CD205/3720). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using CD205 / LY75 / DEC205 Mouse Monoclonal Antibody (CD205/3720).

Product Details

Synonyms

C-type lectin domain family 13 member B; CD205 antigen; CLEC13B; DEC205; gp200 MR6; LY75; Lymphocyte antigen 75; Renal Cell Carcinoma (gp200)

Positive Control

Human tonsil, thymus or lymph node.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

198kDa

Specificity & Comments

DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Related Products



200ug/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Tungekar, M.F., et al. 1996. Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124). Br. J. Cancer 73: 429-432.
  2. Kato, M., et al. 1998. cDNA cloning of human DEC-205, a putative antigen- uptake receptor on dendritic cells.
  3. Immunogenetics 47: 442-450.

Bioinformatics