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CD205 / LY75 / DEC-205 Antibody [CD205/3720]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
4065-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4065-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4065-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
Human tonsil, Thymus or Lymph Node.
Immunogen
Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)
Alternate Names
Lymphocyte antigen 75, C-type lectin domain family 13 member B, DEC-205, gp200-MR6, C-type lectin domain family 13 member B; CD205 antigen; CLEC13B; DEC205; gp200 MR6; LY75; Lymphocyte antigen 75; Renal Cell Carcinoma (gp200)

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CD205/3720
Chromosome Location
2q24.2
Mol. Weight of Antigen
198kDa

Functions

  • Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Key References

  • Tungekar, M.F., et al. 1996. Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124). Br. J. Cancer 73: 429-432.
  • Kato, M., et al. 1998. cDNA cloning of human DEC-205, a putative antigen- uptake receptor on dendritic cells.
  • Immunogenetics 47: 442-450.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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