Home >> Antibodies >> CD137 / 4-1BB / TNFRSF9

CD137 / 4-1BB / TNFRSF9

Recombinant Mouse Monoclonal Antibody [Clone r4-1BB/4603]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603).

SDS-PAGE Analysis Purified CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603).

SDS-PAGE Analysis Purified CD137 Recombinant Mouse Monoclonal Antibody (r4-1BB/4603). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; CDw137; HLDA VI; Homolog of mouse 4 1BB; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of mouse Ly63; T-cell antigen 4-1BB / ILA homolog; Tumor necrosis factor receptor superfamily member 9

Positive Control

HEK293 or Jurkat cells. Human kidney or thyroid cancer tissues. Expressed on the surface of activated T-cells.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

A recombinant fragment (around aa 19-188) of human CD137 protein (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

32kDa (monomer); 85kDa (dimer)

Specificity & Comments

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.