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CD137, Mouse Antibody [LOB12]

In Stock
Catalog Number Formulation Size Price
RTM1-2012-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
RTM1-2012-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
RTM1-2012-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivowhen administered in combination with immune checkpoint inhibitors.

Product Properties & Targets

Antibody Type
Host
Rat
Species Reactivity
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
MPBMC's or Thymus.
Immunogen
Murine CD137 human Fc fusion protein
Alternate Names
Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, T-cell antigen 4-1BB, 4-1BB ligand receptor; 4-1BB, Mouse, homolog; CD137; HLDA VI; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of Mouse Ly63; Ly63, Mouse; Receptor protein 4 1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
LOB12
Chromosome Location
4 E2; 4 81.52 cM (Mouse)
Mol. Weight of Antigen
39kDa

Functions

  • Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Key References

  • Bartkowiak, T., et al. (2015). Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine. Proc Natl Acad Sci U S A 112(38): E5290-5299.
  • Taraban, V. Y., et al. (2002). Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. Eur J Immunol 32(12): 3617-3627.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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