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CD137 / 4-1BB / TNFRSF9

Recombinant Rabbit Monoclonal Antibody [Clone 4-1BB/4552R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded kidney stained with CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).

Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).

Western Blot Analysis of kidney tissue lysate using CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).

Formalin-fixed, paraffin-embedded kidney stained with CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).

Formalin-fixed, paraffin-embedded human kidney stained with CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).

Western Blot Analysis of kidney tissue lysate using CD137 Recombinant Rabbit Monoclonal Antibody (4-1BB/4552R).

Product Details

Synonyms

4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; CDw137; HLDA VI; Homolog of mouse 4 1BB; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of mouse Ly63; T-cell antigen 4-1BB / ILA homolog; Tumor necrosis factor receptor superfamily member 9

Positive Control

HEK293 cells, Jurkat whole cell lysate or recombinant human CD137 protein (WB). Human kidney cancer, liver, stomach or thyroid cancer tissue (IHC-P). Expressed on the surface of activated T-cells.

Known Applications & Suggested Dilutions

ELISA, IF, Flow Cyt, Western Blot, IHC-P More Details

ELISA (For coating, order antibody without BSA)
Immunofluorescence (1-2ug/ml)
Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

A recombinant fragment (around aa 19-188) of human CD137 protein (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

32kDa (monomer); 85kDa (dimer)

Specificity & Comments

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.