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Home >> Antibodies >> CD137 / 4-1BB / TNFRSF9

CD137 / 4-1BB / TNFRSF9

Biotinylated Mouse Monoclonal Antibody [Clone 4-1BB/3201]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab conjugated to Biotin

Catalog No


0.5 ml at 100ug/ml


Purified Ab conjugated to Biotin

Price (USD)


Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Biotin-conjugated CD137 Mouse Monoclonal Antibody (4-1BB/3201).


Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Biotin-conjugated CD137 Mouse Monoclonal Antibody (4-1BB/3201).


Analysis of Protein Array containing more than 19,000 full-length human proteins using CD137-Monospecific Mouse Monoclonal Antibody (4-1BB/3201).

Product Details


4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; CDw137; HLDA VI; Homolog of mouse 4 1BB; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of mouse Ly63; T-cell antigen 4-1BB / ILA homolog; Tumor necrosis factor receptor superfamily member 9

Positive Control

Human kidney cancer, liver, stomach or thyroid cancer tissue (IHC-P). Expressed on the surface of activated T-cells.

Known Applications & Suggested Dilutions

ELISA, IF, Flow Cyt, Western Blot, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Immunofluorescence (2-4ug/ml)
Flow Cytometry (2-4ug/million cells)
Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.


A recombinant fragment (around aa 19-188) of humanCD137/ 4-1BB / TNFRSF9protein (exact sequence is proprietary)

Cellular Localization

Cell Surface

Species Reactivity


Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

32kDa (monomer); 85kDa (dimer)

Specificity & Comments

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.

Related Products

Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Key References

  1. Zhao S, et al. CD137 ligand is expressed in primary and secondary lymphoid follicles and in B-cell lymphomas: diagnostic and therapeutic implications. Am J Surg Pathol. 2013 Feb;37(2):250-8.


  •  Entrez Gene ID: 3604
  •  Gene Symbol: TNFRSF9
  •  SwissProt: Q07011
  •  Chromosome Location: 1p36.23
  •  Unigene: 654459&86447