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Home >> Antibodies >> CD103 / Integrin alpha E (T-Cell Lymphoma & Hairy Cell Leukemia Marker)

CD103 / Integrin alpha E (T-Cell Lymphoma & Hairy Cell Leukemia Marker)

Mouse Monoclonal Antibody [Clone ITGAE/2474]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Small Intestine stained with CD103 Mouse Monoclonal Antibody (ITGAE/2474).

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Formalin-fixed, paraffin-embedded human Colon stained with CD103 Mouse Monoclonal Antibody (ITGAE/2474).

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Formalin-fixed, paraffin-embedded human Tonsil stained with CD103 Mouse Monoclonal Antibody (ITGAE/2474).

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SDS-PAGE Analysis Purified CD103 Mouse Monoclonal Antibody (ITGAE/2474). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using CD103 Mouse Monoclonal Antibody (ITGAE/2474).

Product Details

Synonyms

CD103; Human mucosal lymphocyte antigen 1 (HML1 antigen); Integrin alpha E heavy chain; Integrin alpha E light chain; Integrin alpha E, epithelial-associated; Integrin alpha E1; Integrin alpha-IEL (intestinal intraepithelial lymphocytes); Integrin alpha M290; Integrin alpha-E heavy chain; Integrin, alpha E (ITGAE)

Positive Control

Tonsil, Colon or Stomach.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human ITGAE protein fragment (exact sequence is proprietary)

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

150kDa

Specificity & Comments

This MAb recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E beta-7 (aEb7) integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Antibody to CD103 is an extremely useful addition to the IHC panel for the diagnosis of hairy cell leukemia (HCL).

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Morgan EA, Yu H, Pinkus JL, Pinkus GS. Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody. Am J Clin Pathol. 2013 Feb;139(2):220-30.

Bioinformatics

  •  Entrez Gene ID: 3682
  •  Gene Symbol: ITGAE
  •  SwissProt: P38570
  •  Chromosome Location: 17p13
  •  Unigene: 513867
NBT02474