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Home >> Antibodies >> Cathepsin K (Marker of Tumor Invasiveness)

Cathepsin K (Marker of Tumor Invasiveness)

Mouse Monoclonal Antibody [Clone CTSK/2791]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Liver Carcinoma stained with Cathepsin K Mouse Monoclonal Antibody (CTSK/2791).

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Formalin-fixed, paraffin-embedded human Liver Carcinoma stained with Cathepsin K Mouse Monoclonal Antibody (CTSK/2791).

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Formalin-fixed, paraffin-embedded human Liver stained with Cathepsin K Mouse Monoclonal Antibody (CTSK/2791).

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Formalin-fixed, paraffin-embedded human Liver stained with Cathepsin K Mouse Monoclonal Antibody (CTSK/2791).

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SDS-PAGE Analysis Purified Cathepsin K Mouse Monoclonal Antibody (CTSK/2791). Confirmation of Purity and Integrity of Antibody

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Cathepsin K Mouse Monoclonal Antibody (CTSK/2791)

Product Details

Synonyms

Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CTS02; Ctsk; CTSO1; CTSO2; PKND; PYCD

Positive Control

Human liver or breast tissue (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human Cathepsin K protein (around aa 163-274) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

39kDa

Specificity & Comments

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9.

Bioinformatics

  •  Entrez Gene ID: 1513
  •  Gene Symbol: CTSK
  •  SwissProt: P43235
  •  Chromosome Location: 1q21.3
  •  Unigene: 632466
NBT02791