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Carcinoembryonic Antigen (CEA) / CD66

Mouse Monoclonal Antibody [Clone C66/1009]

Printable

Key References

Bioinformatics

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

499.00

Formulation

Purified Ab conjugated to AF488

Performance Guarantee

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to AF488

Price (USD)

499.00

Printable

Key References

Bioinformatics

Product Details

Synonyms

Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66, Biliary Glycoprotein (BGP-1)

Positive Control

MCF7 or 293T cells. Human colon carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human CEA protein

Cellular Localization

Cytoplasmic and luminal surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

80-200kDa

Specificity & Comments

This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.