Formalin-fixed, paraffin-embedded human tonsilstained with Bcl-2 Mouse Recombinant Monoclonal Antibody (rBCL2/782).
SDS-PAGE Analysis Purified Bcl-2 Mouse Recombinant Monoclonal Antibody (rBCL2/782). Confirmation of Purity and Integrity of Antibody.
Western blot analysis of MCF-7 cell lysate using Bcl-2 Mouse Recombinant Monoclonal Antibody (rBCL2/782).
Formalin-fixed, paraffin-embedded human follicular lymphoma stained with Bcl-2 Recombinant Mouse Monoclonal Antibody (rBCL2/782).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Bcl-2 Mouse Recombinant Monoclonal Antibody (rBCL2/782).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression ofbcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.