SDS-PAGE Analysis Purified Annexin A1 Mouse Monoclonal Antibody (ANEX 5E4/1). Confirmation of Integrity and Purity of the Antibody.
Flow Cytometric Analysis of paraformaldehyde-fixed K562 cells. Annexin A1 Mouse Monoclonal Antibody (ANEX 5E4/1) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.