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Annexin A1 / (Hairy Cell Leukemia Marker) Antibody [ANXA1/1671]

Additional information

Catalog Number: 301-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
301-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
301-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
301-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Annexin A1 / (Hairy Cell Leukemia Marker) Antibody

Formalin-fixed, paraffin-embedded human Spleen tissue stained with Annexin A1 Mouse Monoclonal Antibody (ANXA1/1671).

Annexin A1 / (Hairy Cell Leukemia Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Prostate tissue stained with Annexin A1 Mouse Monoclonal Antibody (ANXA1/1671).

Annexin A1 / (Hairy Cell Leukemia Marker) Antibody - Image 3

SDS-PAGE Analysis of Purified Annexin A1 Mouse Monoclonal Antibody (ANXA1/1671). Confirmation of Integrity and Purity of Antibody.

Annexin A1 / (Hairy Cell Leukemia Marker) Antibody - Image 4

Flow Cytometric Analysis of PFA-fixed HeLa cells. Annexin A1 Mouse Monoclonal Antibody (ANXA1/1671) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Annexin A1 / (Hairy Cell Leukemia Marker) Antibody - Image 5

Western Blot Analysis of A549 cell lysate usingAnnexin A1 Mouse Monoclonal Antibody (ANXA1/1671).

  • Flow
  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
ANXA1/1671
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Apical cell membrane, Basolateral cell membrane, Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Early endosome, Endosome membrane, Extracellular exosome, Extracellular space, Lateral cell membrane, Membrane, Nucleus, Phagocytic cup, Secreted, Secretory vesicle lumen
Gene Name
ANXA1
Positive Control
A431 and K562 cell lysates, human esophagus, placenta and prostate tissues.
Immunogen
Recombinant full length human Annexin A1 protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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MICA Antibody

Additional information

Catalog Number: 100507436-MSM3
Reactivity:

Gene:

Host:

Formalin-fixed, paraffin-embedded human kidney stained with MICA Mouse Recombinant Monoclonal Antibody (MICA/4442). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
5
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MICA Antibody

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Reactivity:

, , , ,

Gene:

Host:

Flow cytometric analysis of PFA-fixed HeLa cells. MEF2B Mouse Monoclonal Antibody (PCRP-MEF2B-2F9) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
2
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Additional information

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Reactivity:

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  • IHC

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Additional information

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Reactivity:

, ,

Gene:

Host:

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with KSP-Cadherin Mouse Monoclonal Antibody (SPM594).
2
  • IHC
  • WB

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Additional information

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Reactivity:

, , , ,

Gene:

Host:

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Additional information

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
  • Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591).
Key References
  • Falini B, Tiacci E, Liso A et al. Lancet 363: 1869-1871, Jun 5, 2004.
  • Basso K, Liso A, Tiacci E et al. J Exp Med 199:59-68, 2004.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
301
SwissProt
P04083
Chromosome Location
9q21.13
Mol. Weight of Antigen
35kDa
Alternate Names
Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35, ANXA1; ANX1; Annexin-1; Chromobindin-9; LPC1; p35

Summary

The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

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