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Recombinant Annexin A1 / (Hairy Cell Leukemia Marker) Antibody [ANXA1/6452R]

Additional information

Catalog Number: 301-RBM12
Reactivity:

, , ,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
301-RBM12-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
301-RBM12-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
301-RBM12-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Annexin A1 / (Hairy Cell Leukemia Marker) Antibody

Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

Recombinant Annexin A1 / (Hairy Cell Leukemia Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

Recombinant Annexin A1 / (Hairy Cell Leukemia Marker) Antibody - Image 3

SDS-PAGE Analysis of Purified ANXA1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R). Confirmation of Purity and Integrity of Antibody.

Annexin A1 Antibody in Western Blot (WB)

Annexin A1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Intestine, Human Lung and A549 lysates using Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

Annexin A1 Antibody in Western Blot (WB)

Annexin A1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Lung, Mouse Lung, Rat Lung, Hamster Lung, Guinea pig Lung and Rabbit Lung tissue lysates using Annexin A1 Recombinant Mouse Monoclonal Antibody (rANXA1/9145).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Guinea Pig, Hamster, Human, Rabbit
Clone
ANXA1/6452R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Apical cell membrane, Basolateral cell membrane, Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Early endosome, Endosome membrane, Extracellular exosome, Extracellular space, Lateral cell membrane, Membrane, Nucleus, Phagocytic cup, Secreted, Secretory vesicle lumen
Gene Name
ANXA1
Positive Control
Human Intestine, lung, A549 cells. Human esophagus, Placenta or Prostate.
Immunogen
Recombinant full-length human Annexin A1 protein
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Reactivity:

, ,

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Formalin-fixed, paraffin-embedded human kidney stained with MICA Mouse Recombinant Monoclonal Antibody (MICA/4442). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
5
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Reactivity:

, , , ,

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Flow cytometric analysis of PFA-fixed HeLa cells. MEF2B Mouse Monoclonal Antibody (PCRP-MEF2B-2F9) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
2
  • Flow
  • IF
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Additional information

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Reactivity:

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Host:

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)
6
  • IHC
  • WB
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Additional information

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Gene:

Host:

Reactivity:

SDS-PAGE Analysis of Purified CDH16 Rabbit Recombinant Monoclonal Antibody (CDH16/7027R). Confirmation of Purity and Integrity of Antibody.
5
  • IHC
  • WB

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Additional information

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Gene:

Host:

Reactivity:

Formalin-fixed, paraffin-embedded human heart stained with N-Cadherin Recombinant Mouse Monoclonal Antibody (rCDH2/1426).
2
  • IHC
  • WB

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Additional information

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Gene:

Host:

Reactivity:

VIEW ALL ANTIBODIES

Other Information

Functions
  • Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity).
  • Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:22879591, PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591).
Key References
  • Falini B., et al. Lancet 363: 1869-1871, Jun 5, 2004.
  • Basso K., et al.J Exp Med199:59-68, 2004.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
301
SwissProt
P04083
Chromosome Location
9q21.13
Mol. Weight of Antigen
35kDa
Alternate Names
Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35, ANXA1; ANX1; Annexin-1; Chromobindin-9; LPC1; p35

Summary

The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

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