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Home >> Antibodies >> Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)

Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)

Recombinant Rabbit Monoclonal Antibody [Clone AKR1B1/7010R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml.

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml.

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human kidney stained with Aldose Reductase Recombinant Rabbit Monoclonal Antibody (AKR1B1/7009R). HIER: Tris/EDTA, pH9.0, 45min. 2░: HRP-polymer, 30min. DAB, 5min.

img

IHC analysis of formalin-fixed, paraffin-embedded human brain. Staining using AKR1B1/7010R at 2ug/ml in PBS for 30min RT. Inset: PBS instead of primary antibody; secondary only negative control.

img

SDS-PAGE Analysis Purified AKR1B1 Rabbit Monoclonal Antibody (AKR1B1/7010R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

AKR1B1; Aldehyde reductase; aldehyde reductase 1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase

Positive Control

MOLT4, Jurkat or Raji cells. Human kidney or colon carcinoma.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length AKR1B1 protein

Cellular Localization

Cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

37kDa

Specificity & Comments

AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bohren, K.M., et al. J. Biol. Chem. 264: 9547-9551.
  2. Lefranc╠žois-Martinez, Anne-Marie, et al. OUP Academic, Oxford University Press, 1 June 2004.

Bioinformatics

  •  Entrez Gene ID: 231
  •  Gene Symbol: AKR1B1
  •  SwissProt: P15121
  •  Chromosome Location: 7q33
  •  Unigene: 521212