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Recombinant MUM1 / IRF4 (Transcription Factor) Antibody [MUM1/8560R]

In Stock
Catalog Number Formulation Size Price
3662-RBM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3662-RBM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3662-RBM5-P1BX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus.
Gene Name
Positive Control
Human tonsil or diffuse large B-cell lymphoma (DLBCL).
Immunogen
Recombinant fragment (corresponding to C-terminal) of IRF4 protein (exact sequence is proprietary)
Alternate Names
Interferon regulatory factor 4, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, NF-EM5, Interferon regulatory factor 4; IRF 4; LSIRF; Lymphocyte specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NFEM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; Transcriptional activator PIP

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
MUM1/8560R
Chromosome Location
6p25.3
Mol. Weight of Antigen
52kDa

Functions

  • Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

Key References

  • Grossman A, Hans-Willi Mittrucker, Nicholl J, et al. Genomics, 1996, 37(2):0-233.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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