Recombinant MUM1 / IRF4 (Transcription Factor) [MUM1/8560R]



MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

Product Properties & Targets

Species Reactivity
Cellular Localization
Gene Name
Positive Control
Human tonsil or diffuse large B-cell lymphoma (DLBCL).
Recombinant fragment (corresponding to C-terminal) of IRF4 protein (exact sequence is proprietary)
Alternate Names
Interferon regulatory factor 4, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, NF-EM5, Interferon regulatory factor 4; IRF 4; LSIRF; Lymphocyte specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM1; NFEM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; Transcriptional activator PIP

Database Links

Entrez Gene ID

Additional Information

Human Gene Symbol
Chromosome Location
Mol. Weight of Antigen


  • Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Grossman A, Hans-Willi Mittrucker, Nicholl J, et al. Genomics, 1996, 37(2):0-233.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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