LRG1 / Leucine Rich alpha-2-glycoprotein 1 [LRG1/4883]

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Summary

LRG1 (leucine-rich 伪2-glycoprotein), also known as LRG, is a 347 amino acid secreted protein that contains 8 LRR (leucine-rich) repeats and one LRRCT domain. The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, cell adhesion and development. Found mainly in plasma, LRG1 is expressed during granulocyte differentiation. The gene that encodes LRG1 consists of nearly 3,000 bases and maps to human chromosome 19p13.3. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs).

Product Properties & Targets

Host
Applications
Species Reactivity
Isotype
Cellular Localization
Secreted
Light Chain
Gene Name
Positive Control
Human liver, pancreas or breast.
Immunogen
Recombinant fragment (around aa 30-180) of human LRG1 protein (exact sequence is proprietary)
Alternate Names
Leucine-rich alpha-2-glycoprotein, A2GL; HMFT1766; Leucine-rich alpha-2-glycoprotein 1; Leucine-rich alpha-2-glycoprotein precursor

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
LRG1/4883
Human Gene Symbol
LRG1
Chromosome Location
19p13.3
Mol. Weight of Antigen
38kDa

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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