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GATA-3 (Breast and Urothelial Marker) Antibody [GATA3/2442]

In Stock
Catalog Number Formulation Size Price
2625-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2625-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2625-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with GATA-3 Mouse Monoclonal Antibody (GATA3/2442).

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with GATA-3 Mouse Monoclonal Antibody (GATA3/2442).

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with GATA-3 Mouse Monoclonal Antibody (GATA3/2442).

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with GATA-3 Mouse Monoclonal Antibody (GATA3/2442).

SDS-PAGE Analysis of Purified GATA-3 Mouse Monoclonal Antibody (GATA3/2442). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified GATA-3 Mouse Monoclonal Antibody (GATA3/2442). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

GATA-3 is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types. GATA-3 expression is primarily seen in breast and urothelial carcinomas.'Therefore, GATA3 antibody can be useful in the identification of unknown primary carcinoma when carcinomas of the breast or bladder are a possibility.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cancer, Cardiovascular, Immunology, Cytokine Signaling, Nuclear Marker, Signal Transduction, Transcription Factors
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Nucleus
Gene Name
GATA3
Positive Control
MCF-7 or T47D cells. Breast or Bladder Carcinoma.
Immunogen
Recombinant fragment of human GATA3 protein (around aa 357-436) (exact sequence is proprietary)
Alternate Names
Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3; GATA binding protein-3; GATA-binding factor 3; GATA3; HDR; HDRS; Transacting T-cell-specific transcription factor GATA-3

Database Links

Entrez Gene ID
2625
SwissProt
P23771

Additional Information

Clone
GATA3/2442
Chromosome Location
10p14
Mol. Weight of Antigen
~50kDa

Related Antibodies

View All GATA3 Antibodies

Functions

  • Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity).

Key References

  • Higgins JP, et al. Am J Surg Pathol. 2007; 31:673-680.
  • Liu H, et al. Am J Clin Pathol. 2012; 138:57-64.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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