PARTNERSHIP OPPORTUNITIES
SDS-PAGE Analysis of Purified FOXI1 Mouse Monoclonal Antibody (PCRP-FOXI1-1F8). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence analysis of PFA-fixed HeLa cells. FOXI1 Mouse Monoclonal Antibody (PCRP-FOXI1-1F8) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Flow cytometric analysis of PFA-fixed HeLa cells. FOXI1 Mouse Monoclonal Antibody (PCRP-FOXI1-1F8) followed by goat anti-mouse IgG-CF488 (blue), unstained cells (red).
Formalin-fixed, paraffin-embedded human prostate stained. FOXI1 Mouse Monoclonal Antibody (PCRP-FOXI1-1F8) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.
Analysis of HuProt™ Protein Array (21,000+ full-length human proteins) with FOXI1 Mouse Monoclonal Antibody (PCRP-FOXI1-1F8). Z-score: Signal strength (in SD above the mean) of antibody binding to each protein. S-score: Difference in Z-scores between the top target and the next best hit, indicating relative specificity. An antibody is considered specific if S ≥ 2.5. Example: Binding to protein X (Z = 43) vs protein Y (Z = 14) → S = 29.
FOXI1 (forkhead box I1), also known as HFH3 (HNF-3/forkhead homolog 3), FKHL10 or FREAC6 (forkhead related transcription factor 6), is a member of the FOX family of transcription factors. The FOX family is a large group of proteins (consisting of at least 43 members) that share a common DNA binding domain termed winged-helix or forkhead domain. FOX transcription factors play important roles in development, differentiation, aging and hormone responsiveness. Localizing to the nucleus, FOXI1 functions as a transcription factor. Mice with mutated forms of FOXI1 show defects in ear development, implying that FOXI1 plays a significant role in the developmental pathway of ears and, in particular, the cochlea and vestibulum. FOXI1 is an upstream transcription regulator of Pendrin (a protein associated with deafness), suggesting a role for FOXI1 in the pathogenesis of Pendred syndrome (PS), a condition of nonsyndromic hearing loss and enlarged vestibular aqueduct (EVA).
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