Formalin-fixed, paraffin-embedded human basal cell carcinoma stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).
Formalin-fixed, paraffin-embedded human basal cell carcinomastained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Cytokeratin 6A (KRT6A) Mouse Monoclonal Antibody (KRT6A/2368).
SDS-PAGE Analysis Purified Cytokeratin 6A Mouse Monoclonal Antibody (KRT6A/2368). Confirmation of Integrity and Purity of Antibody.
Flow cytometric analysis of PFA-fixed HeLacells. KRT6AMouse Monoclonal Antibody (KRT6A/2368) followed bygoat anti-mouse IgG-CF488 (blue); isotype control (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Cytokeratin 6A(KRT6A) Mouse Monoclonal Antibody (KRT6A/2368). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
This MAb recognizes a protein of 56kDa, identified as cytokeratin 6A (KRT6A). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Cytokeratin 6A is the dominant form in epithelial tissue. Cytokeratin 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express KRT6 and KRT16. KRT6 is strongly expressed in about 75% of head and neck squamous cell carcinomas..
