Formalin-fixed, paraffin-embedded human tonsil stained with CD44 Rabbit Recombinant Monoclonal Antibody (HCAM/4110R).

Formalin-fixed, paraffin-embedded human tonsil stained with CD44 Rabbit Recombinant Monoclonal Antibody (HCAM/4110R).

Formalin-fixed, paraffin-embedded human tonsil stained with CD44 Rabbit Recombinant Monoclonal Antibody (HCAM/4110R).

CD44 / HCAM Std. [HCAM/4110R]

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Summary

CD44 is an adhesion molecule, which binds hyaluronic acid and participates in a number of cell-cell interactions, including lymphocyte homing.CD44 is expressed on approximately 90% of lymphocytes, monocytes, granulocytes, and, in lower amounts on thymocytes, fibroblasts, and erythrocytes. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.

Product Properties & Targets

Host
Rabbit
Species Reactivity
Human
Isotype
IgG
Cellular Localization
Cell membrane, Cell projection, Microvillus
Gene Name
CD44
Mol. Weight of Antigen
82kDa
Immunogen
Synthetic peptide corresponding to residues withinaa150 to aa250 of CD44 was used as an immunogen.

Database Links

Entrez Gene ID
960
Unigene
502328
SwissProt
P16070

Additional Information

Clone
HCAM/4110R
Human Gene Symbol
CD44
Chromosome Location
11p13

Known Applications & Suggested Dilutions

  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Schlossman SF, et. al. Leucocyte Typing V, p1713-1719, Oxford Univ. Press, 1995.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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