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CD4, Mouse (T-Cell Marker) Antibody [GK1.5]

Additional information

Catalog Number: RTM1-2009
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
RTM1-2009-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
RTM1-2009-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
RTM1-2009-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD4 Antibody in SDS-PAGE

CD4 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified T-cell surface glycoprotein CD4 Rat Monoclonal Antibody (GK1.5). Confirmation of Purity and Integrity of Antibody.

  • ELISA
  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Rat Monoclonals
Host
Rat
Applications
ELISA, Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Clone
GK1.5
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CD4
Positive Control
Spleen, Thymus or Lymph Node.
Immunogen
Mouse CTL clone V4
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Key References
  • Frei K, et al. 1997. J. Exp. Med. 185:2177. (IHC)
  • Wu L, et al. 1991. J. Exp. Med. 174:1617. (Costim)
  • Godfrey DI, et al. 1994. J. Immunol. 152:4783. (Block)
  • Gavett SH, et al. 1994. Am. J. Respir. Cell. Mol. Biol. 10:587. (Deplete)
  • Felix NJ, et al. 2007. Nat. Immunol. 8:388. (Block)
  • Schuyler M, et al. 1994. Am. J. Respir. Crit. Care Med. 149:1286. (Deplete)
  • Zheng B, et al. 1996. J. Exp. Med. 184:1083. (IHC)
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
12504
SwissProt
P06332
Chromosome Location
6 F2; 6 59.17 cM (Mouse)
Mol. Weight of Antigen
55kDa
Alternate Names
T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, CD4 (L3T4); CD4; CD4+ Lymphocyte deficiency, included; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Summary

CD4 is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosine kinase, lck. CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.

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