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  • HuProt™ Validated, PCRP

AGO3 (Argonaute-3) / eIF2C3 Antibody [PCRP-AGO3-1C5]

These antibodies are validated on HuProt™ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 192669-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
192669-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
192669-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
192669-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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AGO3 (Argonaute-3) / eIF2C3 Antibody

SDS-PAGE Analysis of Purified AGO3 Mouse Monoclonal Antibody (PCRP-AGO3-1C5). Confirmation of Purity and Integrity of Antibody.

AGO3 (Argonaute-3) / eIF2C3 Antibody - Image 2

Flow cytometric analysis of PFA-fixed HeLa cells. AGO3Mouse Monoclonal Antibody (PCRP-AGO3-1C5) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).

AGO3 (Argonaute-3) / eIF2C3 Antibody - Image 3

Immunofluorescence Analysis of PFA-fixed HeLa cells. Cytoplasmic P-bodies and nucleoplasm stained using PCRP-AGO3-1C5

AGO3 (Argonaute-3) / eIF2C3 Antibody - Image 4

followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).

  • ELISA
  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Clone
PCRP-AGO3-1C5
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, P-body
Gene Name
AGO3
Positive Control
HeLa, MCF7 or U-2OS cells.
Immunogen
Recombinant full-length human AGO3 protein
Storage & Stability
Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713).
Key References
  • Blackshaw S, et al. Nature methods 15.5 (2018 May): 330-338.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
192669
SwissProt
Q9H9G7
Chromosome Location
1p34.3
Mol. Weight of Antigen
97.36kDa
Alternate Names
Protein argonaute-3, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3, argonaute 3; Argonaute3; eIF 2C 3; eIF-2C 3; eIF2C 3; Eif2c3; EIF2C3 protein; Eukaryotic translation initiation factor 2C 3; Eukaryotic translation initiation factor 2C3; FLJ12765; hAgo3; MGC86946; Protein argonaute-3

Summary

This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as argonaute RISC catalytic component 3.Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5′- and 3′-flanking sequences to the region of guide-target complementarity.

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