Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) has a molecular weight of approximately 130 kDa. It is primarily expressed on the surface of endothelial cells, which line blood vessels, and is also found on platelets, leukocytes, and some hematopoietic cells. It plays a key role in cell adhesion, particularly in the interaction between endothelial cells. It is also involved in regulating leukocyte migration, angiogenesis, and the maintenance of vascular integrity.
PECAM-1 has been implicated in various diseases, including inflammatory disorders and cardiovascular diseases. Inflammatory conditions involve increased expression and activation of platelet endothelial cell adhesion molecule-1 to facilitate leukocyte extravasation and tissue infiltration.
Antibodies against PECAM-1 are commonly used in research to study its expression and localization in tissues. They are employed in immunohistochemistry and flow cytometry to analyze the presence of PECAM-1 on cell surfaces. Notably, its expression patterns can be used diagnostically, as changes in its expression may be associated with vascular or inflammatory diseases.
Synonyms
Platelet endothelial cell adhesion molecule, EndoCAM, GPIIA', PECA1, EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'
Research Areas
Cardiovascular, Immunology, Angiogenesis, Endothelial Cell Marker
