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Home >> Antibodies >> VEGF-R2 / CD309 / Flk-1 / KDR3

VEGF-R2 / CD309 / Flk-1 / KDR3

Rat Monoclonal Antibody [Clone DC101]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified VEGFR2 Rat Monoclonal Antibody (DC101). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CD309; Fetal liver kinase 1 (FLK-1); KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase); KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Vascular endothelial growth factor receptor 2

Positive Control

Mouse epidermoid, renal cell carcinoma, pancreatic or glioblastoma cells.

Known Applications & Suggested Dilutions

Western Blot, Neut.         More Details

Western Blot (Non-reducing) (2-5ug/ml)
Blocks Binding of VEGF to VEGF-R2 (Order Ab without BSA & Azide)
Inhibits VEGF-induced Signaling (Order Ab without BSA & Azide)
Blocks Tumor Growth in mice (Order Ab without BSA & Azide)
Neutralizing
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length Mouse VEGFR2 protein

Cellular Localization

Cell Surface

Species Reactivity

Mouse.

Host / Ig Isotype

Rat / IgG1, kappa

Mol. Weight of Antigen

180-190kDa

Specificity & Comments

This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Witte L, et al. Cancer Metastasis Rev. 1998 Jun;17(2):155-61.

Bioinformatics

  •  Entrez Gene ID: 16542
  •  Gene Symbol: Kdr (Mouse)
  •  SwissProt: 35918
  •  Chromosome Location: 5 C3.3; 5 40.23 cM (Mouse)
  •  Unigene: 285
NBT00531