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Home >> Antibodies >> Tryptase (Mast Cell Marker)

Tryptase (Mast Cell Marker)

Mouse Monoclonal Antibody [Clone TPSAB1/1961]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with Tryptase Mouse Monoclonal Antibody (TPSAB1/1961).

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SDS-PAGE Analysis Purified Tryptase Mouse Monoclonal Antibody (TPSAB1/1961). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Tryptase Mouse Monoclonal Antibody (TPSAB1/1961).

Product Details

Synonyms

Lung Tryptase; Mast cell alpha II Tryptase; Mast cell beta I Tryptase; Mast cell protease 7; Mast cell protease II; MCP7; Pituitary Tryptase; Skin Tryptase; TPS1; TPSAB1; TPSB1; Tryptase 1; Tryptase alpha 1; Tryptase skin

Positive Control

Skin or Tonsil.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Tryptase protein fragment (around aa 115-233) (Exact sequence is proprietary)

Cellular Localization

Secreted and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

31-36kDa

Specificity & Comments

Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Gurish, M.F. and Austen, K.F. 2001. The diverse roles of mast cells. J. Exp. Med. 194: F1-F5.

Bioinformatics

  •  Entrez Gene ID: 7177
  •  Gene Symbol: TPSAB1
  •  SwissProt: Q15661
  •  Chromosome Location: 16p13.3
  •  Unigene: 405479
NBT01961