Home >> Antibodies >> Tenascin C (Stromal Marker for Epithelial Malignancy)

Tenascin C (Stromal Marker for Epithelial Malignancy)

Recombinant Rabbit Monoclonal Antibody [Clone TNC/2981R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Tenascin C Rabbit Recombinant Monoclonal Antibody (TNC/2981R).

SDS-PAGE Analysis Purified Tenascin C Rabbit Recombinant Monoclonal Antibody (TNC/2981R). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Tenascin C Rabbit Recombinant Monoclonal Antibody (TNC/2981R).

SDS-PAGE Analysis Purified Tenascin C Rabbit Recombinant Monoclonal Antibody (TNC/2981R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Cytotactin; Glioma-associated-extracellular matrix antigen; GMEM; GP 150-225; Hexabrachion (HXB); JI; Myotendinous antigen; Neuronectin; TNC

Positive Control

Extracellular matrix in tonsil and blood vessels. Stroma of many tumors such as breast, squamous cell and lung carcinomas. Staining of normal fibroblasts serves as internal positive control.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length TNC protein

Cellular Localization

Connective tissue matrix

Species Reactivity

Human. Does not react with Rat.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

210kDa and 300kDa

Specificity & Comments

In Western blotting, it reacts with two bands of ~MW of 210kDa and 300kDa, identified as two isoforms of Tenascin C. Specificity of this MAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linkedhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.