2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> Squamous Cell Carcinoma Antigen 1

Squamous Cell Carcinoma Antigen 1

Mouse Monoclonal Antibody [Clone CPTC-SERPINB3-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

SDS-PAGE Analysis Purified SqCC Antigen 1 Mouse Monoclonal Antibody (CPTC-SERPINB3-2). Confirmation of Purity and Integrity of Antibody

img

Analysis of Protein Array containing more than 19,000 full-length human proteins using SqCC Antigen 1 Mouse Monoclonal Antibody (CPTC-SERPINB3-2).

Product Details

Synonyms

HsT1196; Protein T4 A; Protein T4-A; SCC; SCCA-PD; SCCA1; SCCAPD; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3; Serpin B3; SERPINB3; Squamous cell carcinoma antigen 1; T4 A; T4-A

Positive Control

U-2197, HaCaT, Squamous cells. Expressed in some hepatocellular carcinoma.

Known Applications & Suggested Dilutions

Western Blot         More Details

Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length SERPINB3 protein

Cellular Localization

Cytoplasm.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

39kDa

Specificity & Comments

Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sheshadri, Namratha, et al. Cancer Research, U.S. National Library of Medicine, 1 Nov. 2014.

Bioinformatics

  •  Entrez Gene ID: 6317
  •  Gene Symbol: SERPINB3
  •  SwissProt: P29508
  •  Chromosome Location: 18q21.33
  •  Unigene: 227948
NBT02250