2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> Serum Amyloid P / APCS

Serum Amyloid P / APCS

Mouse Monoclonal Antibody [Clone APCS/3240]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human Brain stained with Serum Amyloid P Mouse Monoclonal Antibody (APCS/3240).

img

SDS-PAGE Analysis Purified PSA Mouse Monoclonal Antibody (APCS/3240). Confirmation of Integrity and Purity of Antibody.

img

Analysis of Protein Array containing more than 19,000 full-length human proteins using Serum Amyloid P Mouse Monoclonal Antibody (APCS/3240).

Product Details

Synonyms

9.5S alpha 1 glycoprotein; Amyloid P component serum (APCS); Pentaxin related; Pentraxin 2 (PTX2); Serum Amyloid P (SAP); Serum amyloid P component

Positive Control

Human endometrial carcinoma tissue (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

200kDa (oligomeric); 26kDa (non-covalently bound subunit); 30kDa (glycosylated SAP subunit)

Specificity & Comments

Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Castano AP et al. Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med 1:5ra13 (2009).

Bioinformatics

  •  Entrez Gene ID: 325
  •  Gene Symbol: APCS
  •  SwissProt: P02743
  •  Chromosome Location: 1q23.2
  •  Unigene: 507080
NBT03240