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S100A2 / S100 Calcium Binding Protein A2 Antibody [CPTC-S100A2-2]

In Stock
Catalog Number Formulation Size Price
6273-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6273-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6273-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

S100A2 belongs to the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A2 may function as a modulator against excess calcium accumulation in normal human mammary epithelial cells and also have a role in suppressing tumor cell growth. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. Cytoplasmic overexpression may also be of prognostic significance when observed in oral cancer patients, and the S100A2 has also been identified as significantly down-regulated in gastric cancer.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Gene Name
Positive Control
BxPC3 and A431 cell lysates; Skin and squamous cell cervical carcinoma., A549
Immunogen
Recombinant full-length human S100A2 protein
Alternate Names
Protein S100-A2, CAN19, Protein S-100L, S100 calcium-binding protein A2, CAN19; MGC111539; S100L

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CPTC-S100A2-2
Chromosome Location
1q21.3
Mol. Weight of Antigen
11.12kDa

Functions

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.

Key References

  • Wessels D, et al. PLoS ONE 12(3): e0173400.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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