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Home >> Antibodies >> ROR2

ROR2

Mouse Monoclonal Antibody [Clone ROR2/1912]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
img

Formalin-fixed, paraffin-embedded human Kidney stained with ROR2 Mouse Monoclonal Antibody (ROR2/1912).

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SDS-PAGE Analysis Purified ROR2 Mouse Monoclonal Antibody (ROR2/1912). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

BR; CD49 antigen-like family member B; ROR2; Collagen receptor; DX5; Glycoprotein Ia deficiency included (GPIa); Human platelet alloantigen system 5 (HPA5 included); Integrin alpha II (ITGA2); Platelet alloantigen Br(a), included; Platelet glycoprotein Ia/IIa; Platelet membrane glycoprotein Ia; VLA2;

Positive Control

Human breast, pancreas, kidney or GIST.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Human cultured keratinocytes

Cellular Localization

Cell membrane.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG

Mol. Weight of Antigen

120kDa

Specificity & Comments

ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Yu, J., et al. 2016. J. Clin. Invest. 126: 585-598.

Bioinformatics

  •  Entrez Gene ID: 4920
  •  Gene Symbol: ROR2
  •  SwissProt: Q01974
  •  Chromosome Location: 9q22.31
  •  Unigene: 644776, 98255
NBT01912