Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with RBP1 (RBP/872)
Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with RBP1 (RBP/872)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein-1 (RBP1). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein post-transnationally and results in defective delivery and supply to the epidermal cells.