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Retinol Binding Protein-1 (RBP1) Antibody [RBP/872]

In Stock
Catalog Number Formulation Size Price
5947-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5947-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5947-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with RBP1 (RBP/872)

Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with RBP1 (RBP/872)

Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with RBP1 (RBP/872)

Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with RBP1 (RBP/872)

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein-1 (RBP1). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein post-transnationally and results in defective delivery and supply to the epidermal cells.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Goat, Human, Monkey, Mouse, Rabbit, Rat
Research Areas
Infectious Disease
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
RBP4
Positive Control
Hepatic or Ovarian Carcinoma.
Immunogen
Recombinant human retinol binding protein-1 (RBP1)
Alternate Names
Retinol-binding protein 4, Plasma retinol-binding protein, Cellular retinol-binding protein I, CRBP1, CRBP2, RBP1, RBP2, RBP4, RBPC, Retinol binding protein 1, Retinol binding protein 1 cellular, Retinol binding protein 2 cellular, Retinol binding protein 4 plasma

Database Links

Entrez Gene ID
5947; 5948; 5950
SwissProt
P02753; P09455; P50120

Additional Information

Clone
RBP/872
Chromosome Location
10q23.33
Mol. Weight of Antigen
21-25kDa

Related Antibodies

View All RBP4 Antibodies

Functions

  • Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).

Key References

  • Naylor, H.M., et al. 1999. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy-terminus of RBP. Biochemistry 38: 2647-2653.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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