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Home >> Antibodies >> RBP4 / Retinol Binding Protein 4

RBP4 / Retinol Binding Protein 4

Mouse Monoclonal Antibody [Clone RBP4/4314]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Western blot analysis of human kidney and liver tissue lysates using RBP4 Mouse Monoclonal Antibody (RBP4/4314).

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Western blot analysis of human pancreas tissue lysate using RBP4 Mouse Monoclonal Antibody (RBP4/4314).

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Formalin-fixed, paraffin-embedded human kidney stained with RBP4 Mouse Monoclonal Antibody (RBP4/4314) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control.

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Formalin-fixed, paraffin-embedded dog kidney stained with RBP4 Mouse Monoclonal Antibody (RBP4/4314) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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Formalin-fixed, paraffin-embedded cat kidney stained with RBP4 Mouse Monoclonal Antibody (RBP4/4314) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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SDS-PAGE Analysis Purified RBP4 Mouse Monoclonal Antibody (RBP4/4314). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Monospecific RBP4 Mouse Monoclonal Antibody (RBP4/4314).

Product Details

Synonyms

Plasma retinol binding protein 4 (PRBP); RDCCAS; Retinol binding protein 4 interstitial

Positive Control

HeP-G2 cells. Human kidney, pancreas or liver tissues.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa29-148) of human RBP4 protein (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human, Dog and Cat.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

25kDa

Specificity & Comments

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Bioinformatics

  •  Entrez Gene ID: 5950
  •  Gene Symbol: RBP4
  •  SwissProt: P02753
  •  Chromosome Location: 10q23.33
  •  Unigene: 50223